ReviewLife metabolism2026
Metabolic regulation of oocyte maturation and early embryo development in mammals.
Review in Life metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
8 authors.
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Abstract
Metabolism plays a central role in coordinating mammalian oocyte maturation and early embryonic development. The metabolic changes that occur during these stages are essential for the acquisition of developmental competence and successful reproduction. This review summarizes metabolic regulation from oocyte growth and maturation through fertilization and preimplantation development, with particular emphasis on glucose, lipid, and amino acid metabolism, as well as mitochondrial function. We also discuss how metabolic disturbances associated with maternal obesity, ovarian aging, and polyendocrine metabolic ovarian syndrome (formerly termed polycystic ovary syndrome) impair oocyte quality and embryonic developmental potential. By integrating recent insights from multi-omics, live-cell imaging, and genetic studies, we propose a framework for understanding how metabolism not only supports but also actively governs developmental decisions. We further discuss mechanism-based strategies to restore metabolic balance and improve reproductive outcomes.
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Registered trials
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