Evidence map›Paper›PMID 42770028›Full record

ArticleJBMR plus2026

Identification of candidate receptors mediating the osteoanabolic influence of Wnt1.

Kim M Walter, Leon Grahn, Wenbo Zhao, Kenneth Schöneck, Sandra Paradies, Julia Luther, Mubashir Ahmad, Melanie Haffner-Luntzer, Anita Ignatius, Ernesto Bockamp and 3 more

Abstract read
In one paragraph

Article in JBMR plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kim M WalterDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID https://orcid.org/0009-0008-1121-8968
Leon GrahnDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID https://orcid.org/0009-0001-4899-8725
Wenbo ZhaoDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID https://orcid.org/0000-0002-3418-9433
Kenneth SchöneckDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID https://orcid.org/0000-0002-3232-8874
Sandra ParadiesDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID https://orcid.org/0000-0001-7409-7042
Julia LutherDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID https://orcid.org/0000-0002-1245-7070
Mubashir AhmadInstitute of Orthopedic Research and Biomechanics, University Medical Center Ulm, 89081 Ulm, Germany.ORCID https://orcid.org/0000-0001-9012-4039
Melanie Haffner-LuntzerInstitute of Orthopedic Research and Biomechanics, University Medical Center Ulm, 89081 Ulm, Germany.ORCID https://orcid.org/0000-0002-3333-2613
Anita IgnatiusInstitute of Orthopedic Research and Biomechanics, University Medical Center Ulm, 89081 Ulm, Germany.ORCID https://orcid.org/0000-0002-4782-1979
Ernesto BockampInstitute for Translational Immunology and Research Center for Immunotherapy, University Medical Center, Johannes Gutenberg University, 55131 Mainz, Germany.ORCID https://orcid.org/0000-0002-6181-1734
Michael AmlingDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID https://orcid.org/0000-0003-2382-8348
Thorsten SchinkeDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID https://orcid.org/0000-0002-8576-0177
Timur A YorganDepartment of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID https://orcid.org/0000-0002-0712-0983

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although WNT signaling pathways are of central importance for osteoblast regulation, Wnt1 is the only known ligand for which an osteoanabolic function has been demonstrated based on human genetic evidence. The therapeutic potential of Wnt1 was further documented in a transgenic model allowing inducible

Indexed as

Bone histomorphometryFzdGenetic animal modelsOsteoblastsRemodelingWnt1Wnt-signaling

Identifiers

PMID42770028
PMCPMC13592163

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.