Evidence map›Paper›PMID 42769996›Full record

ArticleInorganic chemistry frontiers2026

Metal thiosemicarbazonates as dual mR2 RNR and colchicine-site tubulin inhibitors: from biochemical inhibition to mitotic arrest in MCF-7 breast cancer cells.

Oleg Palamarciuc, Bianca-Iulia Ciubotaru, Alexandru-Constantin Stoica, Michaela Hejl, Marta Hammerstad, Mihaela Balan-Porcarasu, Sergiu Shova, Gerda T Gátszegi, Ana Popović Bijelić, Jóhannes Reynisson and 9 more

Abstract read
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In one paragraph

Article in Inorganic chemistry frontiers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Oleg PalamarciucDepartment of Inorganic Polymers, "Petru Poni" Institute of Macromolecular Chemistry, Romanian Academy Aleea Gr. Ghica Voda 41 A Iasi 700487 Romania.ORCID https://orcid.org/0000-0002-8820-6411
Bianca-Iulia CiubotaruDepartment of Inorganic Polymers, "Petru Poni" Institute of Macromolecular Chemistry, Romanian Academy Aleea Gr. Ghica Voda 41 A Iasi 700487 Romania.
Alexandru-Constantin StoicaDepartment of Inorganic Polymers, "Petru Poni" Institute of Macromolecular Chemistry, Romanian Academy Aleea Gr. Ghica Voda 41 A Iasi 700487 Romania.ORCID https://orcid.org/0000-0003-3812-2428
Michaela HejlInstitute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna Währinger Strasse 42 A-1090 Vienna Austria vladimir.arion@univie.ac.at.
Marta HammerstadSection for Biochemistry and Molecular Biology, Department of Biosciences, University of Oslo P.O. Box 1066 Blindern NO-0316 Oslo Norway.
Mihaela Balan-PorcarasuDepartment of Inorganic Polymers, "Petru Poni" Institute of Macromolecular Chemistry, Romanian Academy Aleea Gr. Ghica Voda 41 A Iasi 700487 Romania.ORCID https://orcid.org/0000-0001-8988-070X
Sergiu ShovaDepartment of Inorganic Polymers, "Petru Poni" Institute of Macromolecular Chemistry, Romanian Academy Aleea Gr. Ghica Voda 41 A Iasi 700487 Romania.ORCID https://orcid.org/0000-0002-1222-4373
Gerda T GátszegiDepartment of Molecular and Analytical Chemistry, University of Szeged Dóm tér 7-8 H-6720 Szeged Hungary.
Ana Popović BijelićFaculty of Physical Chemistry, University of Belgrade 11158 Belgrade Serbia.ORCID https://orcid.org/0000-0003-3121-2391
Jóhannes ReynissonSchool of Allied Health Professions and Pharmacy, Keele University Hornbeam Building Staffordshire ST5 5BG UK.ORCID https://orcid.org/0000-0003-4174-9512
Michael A JakupecInstitute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna Währinger Strasse 42 A-1090 Vienna Austria vladimir.arion@univie.ac.at.ORCID https://orcid.org/0000-0001-7945-1426
Michal ZaliberaInstitute of Physical Chemistry and Chemical Physics, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava SK-81237 Bratislava Slovakia.ORCID https://orcid.org/0000-0002-6527-1982
Peter RaptaInstitute of Physical Chemistry and Chemical Physics, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava SK-81237 Bratislava Slovakia.
Éva A EnyedyDepartment of Molecular and Analytical Chemistry, University of Szeged Dóm tér 7-8 H-6720 Szeged Hungary.ORCID https://orcid.org/0000-0002-8058-8128
Dragos PeptanariuCentre of Advanced Research in Bionanoconjugates and Biopolymers, "Petru Poni" Institute of Macromolecular Chemistry, Romanian Academy Grigore Ghica Voda Alley 41 A 700487 Iasi Romania peptanariu.dragos@icmpp.ro.
Mihaela DascaluDepartment of Inorganic Polymers, "Petru Poni" Institute of Macromolecular Chemistry, Romanian Academy Aleea Gr. Ghica Voda 41 A Iasi 700487 Romania.ORCID https://orcid.org/0000-0002-0278-8124
Maria CazacuDepartment of Inorganic Polymers, "Petru Poni" Institute of Macromolecular Chemistry, Romanian Academy Aleea Gr. Ghica Voda 41 A Iasi 700487 Romania.ORCID https://orcid.org/0000-0003-4952-5548
Ernest HamelMolecular Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick National Laboratory for Cancer Research, National Institutes of Health Frederick Maryland 21702 USA.ORCID https://orcid.org/0000-0003-3648-103X
Vladimir B ArionDepartment of Inorganic Polymers, "Petru Poni" Institute of Macromolecular Chemistry, Romanian Academy Aleea Gr. Ghica Voda 41 A Iasi 700487 Romania.ORCID https://orcid.org/0000-0002-1895-6460

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer cells exploit multiple proliferation pathways, making single-target therapies vulnerable to resistance. Here, a thiosemicarbazone-based strategy is introduced for striking two validated oncotargets, the R2 subunit of ribonucleotide reductase (RNR) and the colchicine site of tubulin, with one agent. Guided by molecular docking, quinoline-8-carboxaldehyde

Identifiers

PMID42769996
PMCPMC13592152

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.