ArticleFrontiers in nutrition2026
Impact of long-term fasting on liver and abdominal adipose tissues monitored by quantitative chemical-shift encoded MRI.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aims: This study used quantitative Magnetic Resonance Imaging (MRI) to explore lipid metabolism changes during a 12-day fasting intervention in the liver and abdominal adipose tissue (AT). Methods: MRI was performed on 32 participants in the GENESIS clinical trial. This prospective, monocentric, single-arm interventional study evaluated body composition changes at four time points: before, at the end of 12 fasting days, and at 1 and 4 months after refeeding. The MRI protocol included a whole-body multi-step Dixon 3D gradient-echo sequence and a 3D chemical-shift encoded (CSE) pulse sequence to quantify different MRI metrics, such as proton density fat content (PDFF), fatty acid composition [proportion of saturated, monounsaturated, and polyunsaturated fatty acids (FA)], and T Findings: Fasting strongly reduced the liver volume ( Interpretation: CSE-MRI enables fast, injection-free, and quantitative monitoring of abdominal organs during fasting. Our results suggest that long-term fasting can help prevent metabolic dysfunction-associated fatty liver disease by reducing liver fat and promoting a lasting reduction in high-risk visceral fat.
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