ReviewFrontiers in cellular and infection microbiology2026
Gut microbiomes-host immune response and organ dysfunction across the gut-lung, gut-brain, and gut-liver axes.
Review in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Microbial dysbiosis is associated with the onset and progression of disease and may influence host organ function through alterations in microbial metabolites, epithelial integrity, and immune signaling The gut communicates with distant organs through interconnected gut-lung, gut-brain, and gut-liver axes that contribute to physiological homeostasis. In the gut, short-chain fatty acid (SCFA)-producing microbes enhance mucin synthesis, epithelial barrier integrity, and immune regulation, while reduced intestinal pH may limit pathogen colonisation. In this review, we provide an integrated synthesis of evidence across the gut-lung, gut-brain, and gut-liver axes, focusing on how gut microbial dysbiosis and microbiota-derived metabolites influence host immune regulation and distant-organ function. Within the gut-brain axis, microbial metabolites, including SCFAs, can influence enteroendocrine signaling and vagal communication, thereby contributing to metabolic, emotional, and cognitive processes. Within the gut-liver axis, microbial alterations and metabolites are associated with hepatic metabolic dysfunction, inflammation, and lipid metabolic changes, with experimental evidence suggesting potential protective effects of
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