Evidence map›Paper›PMID 42769810›Full record

ArticleInternational journal of preventive medicine2026

Innate Immune Profile in Diabetes Mellitus Rat Treated with Acalypha Indica Extract: Focus on TLR-2, TLR-4,

Tri Handayani, Ani R Prijanti, Desak G B Krisnamurti, Adisti Dwijayanti, Wilzar Fachri, Rani W Hakim

Abstract read
In one paragraph

Article in International journal of preventive medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tri HandayaniMaster's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya, Jakarta, Indonesia.
Ani R PrijantiDepartment of Medical Biochemistry, Faculty of Medicine,Universitas Indonesia Jl. Salemba Raya, Jakarta, Indonesia.
Desak G B KrisnamurtiDepartment of Medical Pharmacy, Faculty of Medicine,Universitas Indonesia Jl. Salemba Raya, Jakarta, Indonesia.
Adisti DwijayantiDepartment of Medical Pharmacy, Faculty of Medicine,Universitas Indonesia Jl. Salemba Raya, Jakarta, Indonesia.
Wilzar FachriDepartment of Medical Pharmacy, Faculty of Medicine,Universitas Indonesia Jl. Salemba Raya, Jakarta, Indonesia.
Rani W HakimDepartment of Medical Pharmacy, Faculty of Medicine,Universitas Indonesia Jl. Salemba Raya, Jakarta, Indonesia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: Twenty-five Sprague-Dawley rats were divided into five groups: the normal group, high fructose and cholesterol (HFC) group, HFC + Ai 250 mg/kgBW group, HFC + Ai 400 mg/kgBW group and HFC + pioglitazone (Pgz) group. After 12 weeks, the rats were sacrificed. The liver tissue was taken to measure the levels of TLR2 and TLR4 using the ELISA method. The expression of the Results: Ai extract at a dose of 400 mg/kgBW could reduce random blood glucose (RBG) levels ( Conclusions: Ai extract can reduce RBG and FBG but cannot reduce inflammation in the liver.

Indexed as

Acalypha indicaArg1diabetes mellitusNos2TLR

Identifiers

PMID42769810
PMCPMC13592885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.