ArticleArchives of rehabilitation research and clinical translation2026
Using Patient-Reported Outcome Measures to Identify Mobility Limitation in Incurable Cancer.
Article in Archives of rehabilitation research and clinical translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Objectives: To (1) examine the relationship between a single-item and multicomponent patient-reported outcome measure (PROM) for mobility; (2) identify mobility profiles (PROM-defined patterns of mobility difficulty) using these measures; and (3) explore associations between demographic or clinical characteristics and mobility profiles. Design: Analysis of baseline data from an ongoing multinational trial of a rehabilitation intervention for people with incurable cancer. Setting: Oncology and palliative care outpatient services participating in an international rehabilitation trial. Participants: A consecutive sample of 211 adults with incurable solid tumors, Eastern Cooperative Oncology Group Performance Status 2-3, and a clinician estimated prognosis of ≥3 months. Of these, 206 had complete mobility data and formed the analytic sample. Main Outcome Measures: Mobility was assessed using the Integrated Palliative Care Outcome Scale (IPOS) mobility item and the World Health Organization Disability Assessment Schedule (WHODAS 2.0) mobility subdomain; higher scores reflect greater mobility limitation or difficulty. Secondary outcomes included WHODAS 2.0 self-care and participation scores and quality of life measured using the Functional Assessment of Cancer Therapy-General. Results: IPOS and WHODAS 2.0 mobility scores were positively correlated (ρ=0.650; 95% CI, 0.55-0.74; Conclusions: A single-item PROM identified broad functional limitations and may help identify mobility profiles among people with incurable cancer. These findings support the utility of the IPOS mobility item as a tool that may help clinicians screen for difficulties with mobility and determine when detailed assessment or rehabilitation input is warranted. The PROM-defined mobility profiles should be interpreted as exploratory stratification and not as independently validated clinical subtypes. Further studies should validate the mobility profiles' stability and clinical usefulness in longitudinal cohorts.
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