ArticleJournal of pain research2026
Association of Preoperative Systemic Inflammatory Indices with Early Postoperative Pain and Function After Total Knee Arthroplasty: A Retrospective Cohort Study.
Article in Journal of pain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Early postoperative pain and impaired function remain common after total knee arthroplasty (TKA). This study evaluated whether associations with early pain and 6-week function were consistent across six related preoperative complete-blood-count-derived inflammatory indices. Methods: This retrospective single-center cohort study included 114 patients who underwent unilateral primary TKA. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI) were calculated from blood samples obtained within 48 hours before surgery. Primary outcomes were numeric rating scale (NRS) pain at 24 hours and Hospital for Special Surgery (HSS) score at 6 weeks. Each index was entered separately into covariate-adjusted models; sensitivity analyses additionally adjusted for ASA grade, C-reactive protein, or erythrocyte sedimentation rate. Results: Higher values of all six indices were associated with higher NRS-24 hour scores and lower 6-week HSS scores. NLR, SII, and SIRI were also associated with greater 72-hour opioid use. In the descriptive NLR comparison, the unadjusted between-group differences were 1.41 points for NRS-24-hour pain and 5.71 points for 6-week HSS. Sensitivity analyses for the primary outcomes were materially unchanged. Exploratory discrimination beyond the clinical base model was modest (highest AUC, 0.702 for the SII-extended model). Conclusion: Higher preoperative CBC-derived inflammatory indices, particularly NLR, SII, and SIRI, were associated with greater early pain burden and lower 6-week function after TKA. They are exploratory adjunctive signals rather than validated stand-alone screening tests or substitutes for clinical judgment. The retrospective single-center design, modest sample, and short follow-up require prospective multicenter validation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.