ArticleSleep advances : a journal of the Sleep Research Society2026
A pilot study investigating the effect of serum 25-hydroxyvitamin D on device-estimated sleep metrics in young black women: a single-arm open-label clinical trial.
Article in Sleep advances : a journal of the Sleep Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05656742 (Effects of Vitamin D on Cardiovascular Health in Black Women), which is not on this map. Not yet cited in PubMed.
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Effects of Vitamin D on Cardiovascular Health in Black Women
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Abstract
Study Objectives: Vitamin D deficiency has been linked to poor sleep health outcomes in the general population. Black women (BLW) experience a higher prevalence of vitamin D deficiency and short and disturbed sleep compared with other races. Therefore, this study tested cross-sectional associations between serum 25-hydroxyvitamin D concentration ([25(OH)D]) and sleep health estimates in young adult BLW, followed by an 8-week vitamin D supplementation intervention. Materials and Methods: Forty-three 18-30-year-old BLW underwent blood sampling for serum [25(OH)D]. Sleep metrics were derived from 14-days of wrist accelerometry. Thereafter, participants with [25(OH)D] <30 ng/ml (N = 16) completed an 8-week vitamin D3 supplementation intervention (5000 IU/day) and repeated blood sampling and sleep monitoring. Results: Linear regressions demonstrate significant cross-sectional associations for [25(OH)D] with sleep efficiency (β = 0.11, Conclusions: [25(OH)D] was cross-sectionally associated with sleep efficiency and SOSD, however, intervention results from this pilot study do not demonstrate a beneficial effect of vitamin D on several device-estimated sleep metrics in young BLW. Clinical Trial Registration: Effects of Vitamin D on Cardiovascular Health in Black Women, https://clinicaltrials.gov/study/NCT05656742?locStr=Delaware&country=United%20States&state=Delaware&cond=Vitamin%20D%20Deficiency&term=blood%20pressure&intr=Vitamin%20D&rank=1 Registered on ClinicalTrials.gov ID NCT05656742.
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