Evidence map›Paper›PMID 42769697›Full record

ArticleRSC chemical biology2026

Discovery of PROTACs recruiting the E3 ligase CHIP.

Tokiha Masuda-Ozawa, Shusuke Tomoshige, Eisuke Hayakawa, Shinichi Sato, Kenji Ohgane, Fumiaki Ohtake, Minoru Ishikawa

Abstract read
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In one paragraph

Article in RSC chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tokiha Masuda-OzawaGraduate School of Life Sciences, Tohoku University 2-1-1 Katahira, Aoba-ku Sendai 980-8577 Japan.ORCID https://orcid.org/0009-0000-3835-5382
Shusuke TomoshigeGraduate School of Life Sciences, Tohoku University 2-1-1 Katahira, Aoba-ku Sendai 980-8577 Japan.ORCID https://orcid.org/0000-0002-4948-5809
Eisuke HayakawaGraduate School of Life Sciences, Tohoku University 2-1-1 Katahira, Aoba-ku Sendai 980-8577 Japan.
Shinichi SatoGraduate School of Life Sciences, Tohoku University 2-1-1 Katahira, Aoba-ku Sendai 980-8577 Japan.ORCID https://orcid.org/0000-0002-8563-1658
Kenji OhganeDepartment of Chemistry, Ochanomizu University 2-1-1 Otsuka, Bunkyo-ku Tokyo 112-8610 Japan.ORCID https://orcid.org/0000-0003-0565-6503
Fumiaki OhtakeLaboratory of Protein Degradation, Institute for Advanced Life Sciences, Hoshi University 2-4-41 Ebara, Shinagawa-ku Tokyo Japan.
Minoru IshikawaGraduate School of Life Sciences, Tohoku University 2-1-1 Katahira, Aoba-ku Sendai 980-8577 Japan.ORCID https://orcid.org/0000-0002-3937-2261

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proteolysis-targeting chimeras (PROTACs) are promising degraders in targeted protein degradation (TPD) systems. Although more than 600 E3 ubiquitin (Ub) ligases exist in the human genome, only a few E3 ligases have been engaged in PROTACs. It is essential to expand the range of available E3 ligase resources to combat drug resistance caused by their mutations and to find suitable candidates for the degradation of certain target proteins. In this study, we aimed to develop novel PROTACs utilizing the carboxyl terminus of the Hsc70-interacting protein (CHIP) E3 ligase, which was previously unutilized. We designed and synthesized PROTACs conjugated with CHIP ligands and target protein ligands

Identifiers

PMID42769697
PMCPMC13592199

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.