ArticleRSC advances2026
AQbD-based development and validation of an HPLC-PDA method for simultaneous determination of sibutramine, desmethylsibutramine, and didesmethylsibutramine in herbal weight-loss supplements.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Illegal adulteration of herbal weight-loss supplements with sibutramine (SIB) and its structurally related analogues remains a significant public health concern, highlighting the need for reliable, accessible, and cost-effective analytical methods for routine regulatory surveillance. In this study, a high-performance liquid chromatography method coupled with photodiode-array detection was developed, chemometrically optimized using Box-Behnken response surface methodology, and validated for the simultaneous determination of SIB, desmethylsibutramine (DMS), and didesmethylsibutramine (DDMS). The effects of mobile-phase pH, flow rate, and column temperature on chromatographic resolution were systematically evaluated to establish optimum separation conditions. Under the optimized conditions, comprising an InertSustain C18 column with gradient elution using acetonitrile and phosphate buffer (pH 3.9), a flow rate of 1.0 mL min
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