ArticleEpilepsy & behavior reports2026
Comparison of selective amygdalohippocampectomy and anterior temporal lobectomy for mesial temporal lobe epilepsy: a systematic review and meta-analysis.
Article in Epilepsy & behavior reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Anterior temporal lobectomy (ATL) and selective amygdalohippocampectomy (SAH) are the two most widely adopted surgical approaches for drug-resistant mesial temporal lobe epilepsy (MTLE). Although both procedures target seizure control, they differ in extent of resection and potential morbidity. The relative effectiveness of ATL and SAH remains debated, particularly regarding seizure freedom, visual field deficits, and postoperative complications. Objective: To systematically compare seizure freedom (Engel I) rates, Engel III-IV outcomes, visual field deficits, and postoperative complications between ATL and SAH. Methods: A systematic review and Results: • Conclusions: ATL provides superior seizure control compared to SAH, whereas SAH offers measurable advantages in visual and perioperative morbidity. The nonsignificant trend toward poorer seizure outcomes in SAH highlights the importance of patient selection and anatomical considerations. These findings support individualized surgical decision-making for drug-resistant MTLE, balancing seizure freedom against visual and postoperative risks.
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