ArticleFood science & nutrition2026
Broccoli Sprout Extract Restores Renal Lipid Metabolism in High-Fat Diet-Fed Mice Involving Modulation of AMPK/Nrf2 Signaling and the NLRP3 Inflammasome.
Article in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Broccoli sprout extract (BSE) has shown promise in metabolic disorders, but its effect on renal lipid metabolism and injury in high-fat diet (HFD)-fed mice remains unclear. This study demonstrated that 12-week BSE supplementation (600 mg/kg diet) significantly ameliorated HFD-induced renal dysfunction, reducing blood urea nitrogen (BUN) from 6.29 to 3.02 mmol/L (by 52.0%), uric acid (UA) from 56.38 to 17.25 μmol/L (by 69.4%), and serum creatinine (SCr) from 19.21 to 11.54 μmol/L (by 39.9%), while decreasing renal triglycerides (TG) from 3.86 to 2.43 mmol/g (by 37.1%) and total cholesterol (TC) from 19.47 to 14.43 mmol/g (by 25.9%). BSE also restored oxidative balance, increasing superoxide dismutase (SOD) activity from 4.37 to 6.54 U/mg protein (by 49.7%) and total antioxidant capacity (T-AOC) from 1.78 to 2.97 μmol/mg protein (by 66.9%), with a reduction in malonaldehyde (MDA) from 1.68 to 1.19 nmol/mg protein (by 29.2%). Untargeted lipidomics revealed that BSE normalized four lipid mediators linked to lipotoxicity, including CAR 22:1, LPC 16:0, PI-Cer 38:1; O3, and NAE 26:5. Mechanistically, BSE activated AMPK signaling (increasing p-AMPKα2 protein and
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