Evidence map›Paper›PMID 42769578›Full record

ArticleFrontiers in pharmacology2026

CPNE7-derived peptides CDP4 and UG28 as pro-angiogenic factors for endothelial regeneration.

Agata Tymińska, Magdalena Narajczyk, Aneta Skoniecka, Natalia Karska, Milena Deptuła-Knioła, Szymon Mania, Karolina Kondej, Piotr M Skowron, Susanna Miettinen, Sylwia Rodziewicz-Motowidło and 1 more

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Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Agata TymińskaLaboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Department of Anatomy, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.
Magdalena NarajczykBioimaging Laboratory, Faculty of Biology, University of Gdańsk, Gdańsk, Poland.
Aneta SkonieckaLaboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Department of Anatomy, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.
Natalia KarskaDepartment of Biomedical Chemistry, Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland.
Milena Deptuła-KniołaLaboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Department of Anatomy, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.
Szymon ManiaDepartment of Chemistry, Technology and Biotechnology of Food Gdańsk University of Technology, Gdańsk, Poland.
Karolina KondejDepartment of Plastic Surgery, Medical University of Gdańsk, Gdańsk, Poland.
Piotr M SkowronDepartment of Molecular Biotechnology, University of Gdańsk, Gdańsk, Poland.
Susanna MiettinenAdult Stem Cell Group, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Sylwia Rodziewicz-MotowidłoDepartment of Biomedical Chemistry, Faculty of Chemistry, University of Gdańsk, Gdańsk, Poland.
Michał PikułaLaboratory of Tissue Engineering and Regenerative Medicine, Division of Embryology, Department of Anatomy, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeEfficient endothelial regeneration is fundamental to microcirculatory restoration and hard tissue repair. CPNE7 family peptides have previously been shown to regulate osteogenesis and chondrogenesis, however, their involvement in vascular reconstruction has not been explored. EXPERIMENTAL APPROACH: In this study, we investigated the effect of two peptides derived from CPNE7, CDP4 and UG28, on human endothelial cells KEY

resultsUG28 demonstrated the strongest pro-angiogenic activity, enhancing EC proliferation, directional migration, and pseudocapillary network formation, while CDP4 also promoted migration and early vascular organization; neither peptide showed cytotoxicity nor induced immune activation, and both were compatible with chitosan matrices. CONCLUSION AND IMPLICATIONS: CPNE7-derived peptides-especially UG28-are potent and safe pro-angiogenic agents with high translational potential, and their compatibility with chitosan supports their applicability in next-generation regenerative therapies targeting endothelial and microvascular repair.

Indexed as

angiogenic agentsbiomaterial constructsendothelial cellspeptidesregenerative medicine and tissue engineering

Identifiers

PMID42769578
PMCPMC13591009

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.