ArticleAmerican journal of translational research2026
Comparison of systemic vascular resistance index-guided versus conventional fluid management on airway pressure, oxygenation and postoperative recovery in patients undergoing one-lung ventilation for thoracic surgery.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo compare the effects of systemic vascular resistance index (SVRI)-guided goal-directed fluid therapy (GDFT) versus conventional fluid management on perioperative airway pressure, oxygenation, and postoperative recovery in thoracic surgery patients with one-lung ventilation (OLV), and to identify independent risk factors for postoperative pulmonary complications (PPCs).
methodsA total of 386 patients were retrospectively enrolled and randomly split into a training set (n=270) and a validation set (n=116) at a 7:3 ratio. The training set was divided into SVRI group (n=155) and control group (n=115). Baseline data, airway pressure, oxygenation, recovery indicators, and 7-day PPCs were collected. Independent risk factors were screened by logistic regression; a nomogram was constructed and evaluated by ROC and calibration curves.
resultsBaseline characteristics were comparable between the groups (P>0.05). The SVRI group had lower airway pressure, fluid volume, infusion rate, recovery time, and PPCs incidence, as well as better oxygenation and urine output (all P<0.05). Ppeak ≥26.845 cmH
conclusionSVRI-guided GDFT improves perioperative outcomes and reduces PPCs in OLV patients. The four indicators effectively predict PPCs, and their combined detection enhances risk stratification accuracy.
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