ArticleAmerican journal of translational research2026
Association of dynamic changes in ASPECTS perfusion scores derived from dual-time-point multi-post-labeling delay arterial spin labeling with 90-day functional outcome in acute ischemic stroke.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate whether dynamic changes in Alberta Stroke Program Early CT Score (ASPECTS) perfusion scores derived from dual-time-point multi-post-labeling delay arterial spin labeling (multi-PLD ASL) are associated with 90-day functional outcome in patients with acute ischemic stroke (AIS).
methodsThis single-center retrospective study included 464 patients with anterior-circulation AIS who underwent multi-PLD ASL at baseline and approximately 1 week after onset. Cerebral blood flow (CBF)-ASPECTS, cerebral blood volume (CBV)-ASPECTS, arterial transit time (ATT)-ASPECTS, relative perfusion values, and infarct core volume (ICV) were compared between favorable (modified Rankin Scale [mRS] 0-2) and unfavorable (mRS 3-6) outcome groups. Correlation and receiver operating characteristic (ROC) analyses were performed.
resultsThe favorable outcome group showed greater improvements in CBF-ASPECTS, CBV-ASPECTS, ATT-ASPECTS, relative cerebral blood flow (rCBF), and relative cerebral blood volume (rCBV), together with a greater reduction in relative arterial transit time (rATT). Increased ICV was more pronounced in the unfavorable outcome group. Dynamic ASL indicators were significantly correlated with 90-day mRS scores. Single indicators showed moderate discriminative ability, whereas combined models performed better. The clinical-imaging model showed the highest area under the curve (AUC) of 0.846.
conclusionShort-term changes on dual-time-point multi-PLD ASL were associated with 90-day functional outcome in AIS. Dynamic ASPECTS perfusion scores may serve as an interpretable imaging supplement for prognosis assessment, but should be combined with clinical information.
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