ReviewJournal of the Society for Cardiovascular Angiography & Interventions2026
Early Aspirin Discontinuation Following PCI for Acute Coronary Syndromes: A Systematic Review and Meta-Analysis of Reconstructed Individual Patient Data.
Review in Journal of the Society for Cardiovascular Angiography & Interventions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Dual antiplatelet therapy (DAPT) is well established for patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). Contemporary studies demonstrated that a shorter DAPT strategy may reduce bleeding, while preserving ischemic protection. However, optimal timing of aspirin discontinuation remains uncertain. Methods: We performed a systematic review and meta-analysis of randomized controlled trials comparing standard 12-month DAPT versus early aspirin discontinuation (≤1-2 months), following PCI for ACS, excluding studies with immediate aspirin withdrawal. We systematically searched PubMed, Embase, and Cochrane. Individual patient data were reconstructed from Kaplan-Meier (KM) curves. Hazard ratios (HRs) and their 95% CIs were estimated using Cox regression. All statistical analyses were performed using R software, version 4.5.0. Results: We included 5 randomized controlled trials comprising 12,984 patients; 6473 (49.8%) were randomized to early aspirin discontinuation. Short-term DAPT was associated with a reduction in the risk of bleeding (HR, 0.44; 95% CI, 0.34-0.55; Conclusion: In trials evaluating aspirin discontinuation at approximately 1 month following PCI for ACS, transitioning to P2Y
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.