ArticleChemical science2026
Diastereoselective synthesis of substituted cyclopentanones
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We report a straightforward one-step, highly diastereoselective [3 + 2] cycloaddition for the synthesis of cyclopentanones incorporating up to four stereogenic centres. Sulfoxonium ylides are readily available, safe-to-use reagents and were utilised as three-carbon synthons to introduce alkyl, aryl, and heteroatom substituents at the α-positions of the cyclopentanone. A variety of terminal and internal alkenes serve as two-carbon synthons for installation of alkyl, alkenyl, and (hetero)aryl substituents at the β-positions. Depending on the reactant combination, the cycloaddition is best performed either in hexafluoroisopropanol as the reaction solvent or with ZnCl
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