Evidence map›Paper›PMID 42769488›Full record

ArticleComputational and structural biotechnology journal2026

Boosting the Predictive Power of Virus-Specific T-Cell Clinical Trials via Generative Models.

Pamela Chansky, Jeremy Rubinstein, Michael Grimley, Stella M Davies, Emily Blyth, David Gottlieb, Michael A Pulsipher, Catherine Bollard, Michael D Keller, Wei Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pamela ChanskyCenter for Cancer & Immunology Research, Children's National Hospital, Washington, DC, USA.ORCID https://orcid.org/0000-0002-8169-992X
Jeremy RubinsteinDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID https://orcid.org/0000-0002-1934-2954
Michael GrimleyDivision of BMT and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Stella M DaviesDivision of BMT and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Emily BlythBlood Transplant and Cell Therapies Program, Westmead Hospital, Sydney, NSW, Australia.
David GottliebBlood Transplant and Cell Therapies Program, Westmead Hospital, Sydney, NSW, Australia.
Michael A PulsipherDivision of Pediatric Hematology and Oncology, Intermountain Primary Children's Hospital, Huntsman Cancer Institute, Spencer Fox Eccles School of Medicine at the University of Utah, Salt Lake City, UT, USA.ORCID https://orcid.org/0000-0003-3030-8420
Catherine BollardCenter for Cancer & Immunology Research, Children's National Hospital, Washington, DC, USA.ORCID https://orcid.org/0000-0001-5140-9090
Michael D KellerCenter for Cancer & Immunology Research, Children's National Hospital, Washington, DC, USA.ORCID https://orcid.org/0000-0001-8323-3085
Wei LiCenter for Genetic Medicine Research, Children's National Hospital, Washington, DC, USA.ORCID https://orcid.org/0000-0002-2163-7903

Funding

Enhancing efficacy of virus-specific T cell therapy following hematopoietic stem cell transplantation by CD52 knockoutR33HL175692 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI KELLER, MICHAEL DANIEL · 2024 to 2025
$1.1M
NHLBI NIH HHS R33 HL175692
6 · The paper itself

Abstract

The modest number of participants enrolled in phase I/II clinical trials limits the development of accurate models to predict treatment response. This is evidenced by early-phase clinical trials evaluating partially human leukocyte antigen-matched virus-specific T cells (VSTs) to treat virus infections in immunocompromised persons.

Identifiers

PMID42769488
PMCPMC13590963

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.