Single-cell lineage tracing in tumor organoids identifies expansion states depicting the origin and progression of lung adenocarcinoma.

Wutao Chen, Peng Li, Hejian Zhang, Yumeng Sheng, Guoliang Yang, Jing Hu, Bin Yu

Abstract read

In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Wutao Chen *State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Peng Li *State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Hejian Zhang *Department of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Yumeng Sheng *State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Guoliang YangDepartment of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Jing HuDepartment of Anesthesiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Bin YuState Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Only a subset of epithelial cells can initiate progressive lung adenocarcinoma (LUAD), yet the founder cell states that confer this competence remain poorly defined. Methods: We established a barcoded Results: Barcoded organoids generated LUAD-like tumors. Paired barcode recovery identified expanded, diminished and failed lineages and showed that expanded lineages were enriched for surfaceome genes associated with stemness. Among candidate surface markers, Discussion: These findings identify

Indexed as

Adenocarcinoma of LungCell LineageLung NeoplasmsOrganoidsAnimalsDisease ProgressionHumansMiceNeoplastic Stem CellsSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisTumor Suppressor Protein p53Tumor Suppressor Protein p53lineage tracinglung adenocarcinomaorganoidssingle-cell RNA sequencingtumor initiation

Identifiers

PMID42769436

DOI10.3389/fimmu.2026.1903250

PMCPMC13590773

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.