ArticleOncology research2026
cGAS Downregulation Contributes to EGFR-TKI Resistance in NSCLC through the p-Nrf2-SIRT3-ROS/Ferroptosis Axis.
Yawan Zi, Huilin Yu, Xiaohui Wang, Yuezhou Zhang, Shengxin Fan, Jiukang Li, Jian Wang, Ke Liao, Hong Chen
Abstract read
In one paragraphArticle in Oncology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Yawan ZiDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Huilin YuDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xiaohui WangDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yuezhou ZhangDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Shengxin FanDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jiukang LiDepartment of Infectious Diseases, The People's Hospital of Yue Chi County, Guang'an, China.
Jian WangEmergency and Intensive Care Medicine Center, Guang'an People's Hospital, Guang'an, China.
Ke LiaoDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Hong ChenDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Funding
HSRD VA I01 HX000206
6 · The paper itselfAbstract
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Indexed as
Carcinoma, Non-Small-Cell LungDrug Resistance, NeoplasmLung NeoplasmsNucleotidyltransferasesProtein Kinase InhibitorsSirtuin 3AnimalsCell Line, TumorCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDown-RegulationErbB ReceptorsFerroptosisGene Expression Regulation, NeoplasticHumansMiceNF-E2-Related Factor 2cGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseEGFR protein, humanErbB ReceptorsNFE2L2 protein, humanNF-E2-Related Factor 2NucleotidyltransferasesProtein Kinase InhibitorsReactive Oxygen SpeciesSirtuin 3Cyclic GMP-AMP synthaseDNA damage repairEGFR-TKI resistanceferroptosisp-Nrf2-SIRT3-ROS axis
Identifiers
PMID42769423
PMCPMC13591339
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