Evidence map›Paper›PMID 42769396›Full record

ArticleExperimental and therapeutic medicine2026

ACT001 suppresses ox-LDL-mediated macrophage ferroptosis via activating the NRF2 pathway: An

Yangyang Tao, Yuwu Chen, Yonghou Zhao, Jianbo Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental and therapeutic medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yangyang TaoDepartment of Neurology, Heilongjiang Mental Hospital, Harbin, Heilongjiang 150000, P.R. China.
Yuwu ChenDepartment of Cardiology, The Second Affiliated Hospital, Harbin Medical University, State Key Laboratory of Frigid Zone Cardiovascular Diseases, Harbin, Heilongjiang 150000, P.R. China.
Yonghou ZhaoDepartment of Neurology, Heilongjiang Mental Hospital, Harbin, Heilongjiang 150000, P.R. China.
Jianbo CaiDepartment of Neurology, Heilongjiang Mental Hospital, Harbin, Heilongjiang 150000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidized low-density lipoprotein (ox-LDL) is a key inducer of ferroptosis, which is associated with the progression of atherosclerosis. Macrophages play a notable role in atherosclerosis development, and ferroptosis in these cells contributes to the pathological process of atherosclerosis. However, the potential intervention strategy for ox-LDL-induced RAW264.7 cell ferroptosis remains unclear. ACT001 has emerged as a novel anti-inflammation agent; therefore,

Indexed as

ACT001atherosclerosisglutathione peroxidase 4solute carrier family 7 member 11

Identifiers

PMID42769396
PMCPMC13591240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.