ArticleFrontiers in immunology2026
Association of dual-energy CT-derived quantitative parameters with hydroxyproline levels and pulmonary function in nonspecific interstitial pneumonia.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study evaluated the feasibility of dual-energy CT (DECT) for assessing the correlation between hydroxyproline (HYP) levels in lung tissue of patients with nonspecific interstitial pneumonia (NSIP) and lung volume and pulmonary function. Methods: We retrospectively analyzed 99 NSIP patients (51 cellular, 48 fibrotic) and 40 controls. All underwent DECT imaging. Lung HYP‑equivalent density (HYP‑ED) and volume were quantified using spectral post-processing. Pulmonary function parameters, including FVC% Pred and DLCO% Pred, were collected. Intergroup differences, correlations, and diagnostic performance were assessed. Results: Lung volume was higher in controls (3797.40 ± 1155.68 cc) than in cellular (2796.88 ± 334.03 cc) and fibrotic NSIP (2156.76 ± 423.40 cc; Conclusions: DECT enables noninvasive quantification of lung HYP-ED in NSIP. HYP‑ED correlates with disease severity and may serve as a promising imaging biomarker for fibrosis assessment and monitoring.
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