ArticleAmerican journal of translational research2026
Amiodarone-metoprolol co-administration enhances heart rate variability and suppresses inflammatory cytokines in tachyarrhythmia patients.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo elucidate the efficacy of amiodarone (AMD)-metoprolol (MET) co-administration in tachyarrhythmia patients, and to assess its impact on heart rate (HR) variability (HRV) and serum inflammatory cytokines (SICs).
methodsThis study included 188 tachyarrhythmia patients who were treated at the Qinghai Provincial Fourth People's Hospital, including 88 patients treated with AMD (control group) and 100 patients treated with AMD+MET (research group). We compared the following clinical data between groups: curative effects, frequency and duration of arrhythmia episodes, vital signs, cardiac function (left ventricular [LV] ejection fraction [LVEF], LV systolic diameter [LVSD], LV end-diastolic diameter [LVEDD]), HRV, SICs, oxidative stress (superoxide dismutase [SOD], malondialdehyde [MDA]), and side effects. In addition, we explored factors influencing patients' curative effects.
resultsA higher total effective rate was observed in the research group compared with the control group (91.00% vs. 79.55%, P=0.025). In addition, the research group experienced fewer arrhythmia episodes with shorter durations (P<0.001), and a lower incidence of total adverse events (9.00% vs. 23.86%, P=0.006). A more pronounced drop in post-treatment vital signs, LVSD, LVEDD, various SICs, and MDA (all P<0.001), as well as a rise in LVEF (P<0.001), HRV indices (P<0.001), and SOD (P=0.002), were determined in the research group. LVEF, SDNN, and LF at baseline, as well as therapeutic method, independently influenced patients' efficacy.
conclusionAMD in combination with MET yields superior efficacy in tachyarrhythmia patients, significantly improving HRV and suppressing SICs.
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