ArticleAmerican journal of translational research2026
Combined core stability and nutritional therapy are associated with greater functional and nutritional gains in children with spastic cerebral palsy.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo compare 12-month functional and nutritional outcomes among children with spastic cerebral palsy receiving conventional rehabilitation, rehabilitation plus individualized nutrition, or rehabilitation plus nutrition and core stability training.
methodsThis single-center retrospective cohort included 60 children aged 3-12 years with Gross Motor Function Classification System levels I-IV (20 per group). Core training was delivered three times weekly for 30 minutes during a 3-month supervised phase, and nutrition followed an individualized five-step protocol. Outcomes were assessed at baseline and 3, 6, and 12 months. Continuous outcomes were analyzed by repeated-measures and time-specific analysis of variance with Holm-adjusted comparisons. Ordinal outcomes were analyzed non-parametrically.
resultsAge and sex were comparable at baseline. Group-by-time interactions were observed for Gross Motor Function Measure-88 Dimension D (P=0.026), Dimension E (P=0.048), Berg Balance Scale (P<0.01), weight-for-age z-score (P<0.001), and body mass index-for-age z-score (P<0.01). At 12 months, the combined group exceeded the conventional group in Dimension D by 14.11 points (95% CI 6.50-21.72; Holm P=0.002), Dimension E by 13.54 points (95% CI 6.39-20.69; Holm P<0.001), and balance by 11.29 points (95% CI 5.02-17.56; Holm P=0.002). Weight-for-age and body mass index-for-age z-scores were higher by 2.35 and 1.99 units (both Holm P<0.001). Spasticity was lower and strength was higher in the combined group. No serious intervention-related adverse events were documented.
conclusionsComprehensive rehabilitation was associated with larger functional and nutritional gains, but causality could not be established. A stratified randomized trial with blinded assessment and quantified adherence is warranted.
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