ArticleFrontiers in neuroscience2026
Inflammatory burden index is associated with poor functional outcome and stroke-associated pneumonia in patients with primary brainstem hemorrhage: a retrospective cohort study.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Primary brainstem hemorrhage (PBH) is a severe, poorly-prognostic stroke subtype. Since single biomarkers cannot reflect global inflammatory status, we constructed a composite Inflammatory Burden Index (IBI) incorporating neutrophil-to-lymphocyte ratio (NLR), C-reactive protein-to-albumin ratio (CAR), and systemic immune-inflammation index (SII), and assessed its links with 90-day poor functional outcome and stroke-associated pneumonia (SAP) in PBH patients. Methods: This retrospective cohort included 347 PBH patients (2015-2023). The IBI was calculated as 0.50 × NLRz + 0.30 × CARz + 0.20 × SIIz, where the weights were assigned a priori from a qualitative synthesis of prior literature and expert judgment rather than derived from the study data. Patients were stratified into tertiles. Primary outcome was poor 90-day functional outcome (modified Rankin Scale 3-6). Secondary outcomes were 90-day mortality and SAP. Multivariable logistic regression, restricted cubic spline analysis, and decision curve analysis were performed. Incremental value over a reference clinical model (age, Glasgow Coma Scale, hematoma volume, intraventricular hemorrhage) was assessed via DeLong test, net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Results: The overall rates of poor outcome, mortality, and SAP were 30.3, 12.1, and 16.7%, respectively. Higher IBI tertiles were associated with progressively higher rates of poor functional outcome (18.1, 27.8, and 44.8%; Conclusion: IBI independently predicts poor functional outcome and adds incremental value over clinical factors and most individual markers. However, its utility for SAP does not exceed that of NLR alone; hence IBI should be used selectively for functional prognostication, while NLR remains the preferred biomarker for SAP risk assessment, pending further external validation.
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