ArticleAmerican journal of translational research2026
Immunotherapy-combined chemotherapy as first-line treatment for stage IIIB/IV large cell neuroendocrine lung carcinoma.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesThe optimal first-line treatment for advanced large cell neuroendocrine carcinoma of the lung (LCNEC) remains unclear. This study aimed to comprehensively evaluate and compare the efficacy of different first-line treatment regimens in patients with stage IIIB/IV LCNEC.
methodsA retrospective analysis was performed on 93 patients diagnosed with stage IIIB/IV LCNEC at The First Affiliated Hospital of Henan Medical University from March 2017 to December 2022. Based on the initial therapeutic regimen, patients were divided into three groups: chemotherapy alone (Chemotherapy group, n=55), chemotherapy combined with immunotherapy (Immunotherapy+chemotherapy group, n=23), and epidermal growth factor receptor (EGFR)-targeted therapy (Targeted therapy group, n=15; for EGFR-mutant patients). Efficacy was evaluated using objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), and overall survival (OS).
resultsThe Chemotherapy group had a median PFS of 4.3 months and a median OS of 12.3 months. The Immunotherapy+chemotherapy group achieved an ORR of 56.5% and a DCR of 91.3%, with a significantly longer median PFS of 10.6 months compared to the Chemotherapy group (P<0.0001). The Targeted therapy group showed a median PFS of 6.9 months and a median OS of 18.8 months. Notably, the median PFS of the Immunotherapy+chemotherapy group was markedly prolonged relative to the Chemotherapy group (P<0.0001).
conclusionsChemotherapy combined with immunotherapy may be a promising first-line treatment strategy for patients with stage IIIB/IV LCNEC, as it significantly improves PFS compared to chemotherapy alone. Additionally, targeted therapy yields encouraging outcomes in EGFR-mutant patients.
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