ArticleFrontiers in network physiology2026
Quantitative assessment of heart-brain coupling in neonates with hypoxic-ischemic encephalopathy.
Article in Frontiers in network physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hypoxic-ischemic encephalopathy (HIE) remains a critical challenge in neonatal intensive care, requiring precise bedside monitoring to mitigate long-term neurological morbidity. While individual assessment of cerebral and cardiovascular activity is standard, the dynamic interaction between these systems provides untapped diagnostic value. This pilot study investigates neuro-cardiac coupling using synchronized long-term EEG and ECG recordings, focusing primarily on a core subset of 61 neonates classified by clinical HIE severity (Sarnat Stage 1 vs. Stage 2). We employed cross-modal analysis to evaluate the relationship between the amplitude-integrated EEG (aEEG) envelope and heart rate variability (HRV) metrics. Our results demonstrate that neuro-cardiac interaction is significantly modulated by HIE severity and electrocortical background patterns. Neonates with healthy continuous normal voltage (CNV) patterns exhibited robust neuro-cardiac synchronization (median Spearman's
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