ArticleFrontiers in endocrinology2026
From sequence to timescale: a frequency-domain control-theoretic framework linking ncRNA sequence composition to epigenetic regulatory timescales.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Non-coding RNAs (ncRNAs) are central regulators of epigenomic states, orchestrating chromatin modifications, gene silencing, and nuclear architecture through recruitment of chromatin-modifying complexes. Long noncoding RNAs (lncRNAs) such as XIST, HOTAIR, and MALAT1 exemplify these regulatory roles. Despite their importance, quantitative computational frameworks for linking ncRNA sequence composition to temporal regulatory behaviour remain limited. We introduce a frequency-domain control theory framework modelling RNA sequences as cascaded feedback systems, extending a previously established second-order negative feedback model developed for hormonal endocrine axis dynamics (1,2). This paper constitutes the molecular layer beneath that endocrine framework: where the companion paper characterises the cortisol-HPA axis at the hormonal timescale (
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