ArticleAmerican journal of translational research2026
Efficacy and safety of flexible ureteroscopy assisted by a flexible-tip negative pressure suction sheath for 2-4 cm renal calculi.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the efficacy and safety of flexible ureteroscopy assisted by a flexible-tip negative-pressure suction sheath for the treatment of 2-4 cm renal calculi.
methodsWe retrospectively analyzed clinical data from 103 patients with 2-4 cm renal calculi who underwent flexible ureteroscopic holmium laser lithotripsy. Patients were divided into a flexible-tip suction sheath group (n=52) and a conventional sheath group (n=51) according to the type of ureteral access sheath used during surgery. Perioperative findings and surgical complications were compared between the two groups.
resultsThe stone-free rate was significantly higher in the flexible-tip suction sheath group (92.31%) than in the conventional sheath group (76.47%), and hospital stay was significantly shorter (both P < 0.05). The incidences of postoperative fever and steinstrasse in the flexible-tip suction sheath group were 3.85% and 1.92%, respectively, which were significantly lower than the 17.65% and 15.67% observed in the conventional sheath group (both P < 0.05). Postoperatively, serum levels of TNF-α, IL-1β, IL-6, CRP, cortisol, norepinephrine, and adrenocorticotropic hormone increased in both groups; however, the magnitude of elevation was significantly smaller in the flexible-tip suction sheath group (all P < 0.05). In addition, postoperative levels of serum creatinine, cystatin C, blood urea nitrogen, and neutrophil gelatinase-associated lipocalin, as well as 6-month postoperative quality-of-life scores, were significantly better in the flexible-tip suction sheath group than in the conventional sheath group (all P < 0.05).
conclusionThe application of flexible-tip negative-pressure suction sheath-assisted flexible ureteroscopy in patients with 2-4 cm renal calculi was associated with a higher stone-free rate, reduced incidences of specific postoperative complications, and more favorable short-term recovery outcome. This suggests its clinical value. Nevertheless, prospective randomized controlled trials are warranted for further validation.
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