Evidence map›Paper›PMID 42769090›Full record

SynthesisFrontiers in endocrinology2026

Association between type 1 diabetes mellitus and dental caries in children and adolescents: a meta-analysis and Mendelian randomization study.

Keyi Zhu, Fei Gao, Junzhu Yue, Miaoxin Yang, Jingyang Wu, Ruyi Zhao, Duo Li

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Keyi ZhuDept of Stomatology, The Affiliated People's Hospital of Ningbo University, Ningbo University, Ningbo, Zhejiang, China.
Fei GaoDept of Stomatology, The Affiliated People's Hospital of Ningbo University, Ningbo University, Ningbo, Zhejiang, China.
Junzhu YueDept of Stomatology, The Affiliated People's Hospital of Ningbo University, Ningbo University, Ningbo, Zhejiang, China.
Miaoxin YangDept of Stomatology, The Affiliated People's Hospital of Ningbo University, Ningbo University, Ningbo, Zhejiang, China.
Jingyang WuDept of Stomatology, The Affiliated People's Hospital of Ningbo University, Ningbo University, Ningbo, Zhejiang, China.
Ruyi ZhaoDept of Stomatology, The Affiliated People's Hospital of Ningbo University, Ningbo University, Ningbo, Zhejiang, China.
Duo LiDept of Stomatology, The Affiliated People's Hospital of Ningbo University, Ningbo University, Ningbo, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: This study aimed to examine the relationship between type 1 diabetes mellitus (T1DM) and dental caries among children and adolescents through a meta-analysis, and to assess the potential causal link between these conditions using Mendelian randomization (MR) techniques. Methods: A comprehensive literature review was carried out to identify relevant studies, and meta-analyses were conducted utilizing Stata statistical software. For the MR analyses, summary-level data from genome-wide association studies (GWAS) regarding T1DM and dental caries in childhood and adolescence were gathered. Results: The meta-analysis indicated that the decayed, missing, and filled teeth (DMFT) index for permanent teeth was notably higher in children with T1DM compared to the control group, yielding a pooled standardized mean difference (SMD) of 0.19 (95% CI: 0.06-0.31; I Discussion: While children and adolescents with T1DM are at an elevated risk for dental caries, no statistically significant causal link was observed. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/177851 identifier CRD2020177851.

Indexed as

Dental CariesDiabetes Mellitus, Type 1Mendelian Randomization AnalysisAdolescentChildGenome-Wide Association StudyHumansadolescentschildrendental cariesMendelian randomization analysismeta-analysistype 1 diabetes mellitus

Identifiers

PMID42769090
PMCPMC13590302

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.