ArticleFrontiers in medicine2026
Serum phoenixin-14 levels in chronic kidney disease and hemodialysis patients: a cross-sectional study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Phoenixin-14 (PNX-14) is a bioactive peptide associated with mitochondrial function, oxidative stress responses, and cellular protection. Although experimental data suggest a possible role in renal injury, its serum levels in chronic kidney disease (CKD) have not been previously studied. Given the limitations of conventional renal biomarkers, PNX-14 may offer additional information regarding renal dysfunction in CKD. Methods: This single-center, prospective, observational, cross-sectional study included 140 adult patients with Stage 3 CKD ( Results: Serum PNX-14 levels increased progressively with advancing CKD stage, from a median of 17.88 (IQR 15.16-20.20) pg/mL in Stage 3-43.14 (IQR 23.78-95.71) pg/mL in the HD group ( Conclusions: Serum PNX-14 levels increase with worsening CKD stage and are strongly associated with renal function parameters. Its limited change after HD and its discriminative performance suggest that PNX-14 may provide clinically relevant information regarding disease severity in CKD. Further prospective and longitudinal studies are needed to clarify its potential clinical utility.
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