ArticleFrontiers in allergy2026
Allergen-specific IgE sensitization spectrum in 4,166 children with allergic diseases at a county-level hospital in eastern China: a retrospective cross-sectional study.
Article in Frontiers in allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to characterize the serum specific IgE sensitization spectrum in children with allergic diseases at a county-level tertiary hospital and to evaluate age-, sex-, and co-sensitization patterns. Methods: This single-center retrospective cross-sectional study included 4,166 children aged <18 years with allergic diseases who underwent serum specific IgE (sIgE) testing at the First People's Hospital of Taicang City between 2019 and 2024. Twenty allergens (10 inhalant and 10 ingested) were measured by enzyme immunoassay, with sensitization defined as sIgE ≥0.35 kU/L. Sensitization patterns by sex and age were assessed using Results: The overall sensitization rate was 75.85%, with higher positivity in boys than girls (77.46% vs. 73.49%, Conclusion: In this county-level cohort from the northern Yangtze River Delta, pediatric allergen sensitization was dominated by house dust mites and early food allergens, with sex- and age-related differences and distinct co-sensitization patterns. These findings may inform allergen screening and pediatric allergy management in similar regional settings.
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