ArticleAnnals of medicine2026
Association between early systolic blood pressure and clinical outcomes in non-critically ill patients with sepsis-associated acute kidney injury: a retrospective cohort study.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis-associated acute kidney injury (SA-AKI) is associated with poor outcomes. Evidence regarding the relationship between early systolic blood pressure (BP) and clinical outcomes in non-critically ill patients with SA-AKI remains limited. This study aimed to investigate the association between mean systolic BP during the first 48 h after admission and one-year clinical outcomes in this population.
methodsWe conducted a single-center retrospective cohort study of non-critically ill adults with SA-AKI admitted between 2011 and 2020. SA-AKI was defined by a sequential organ failure assessment (SOFA) score increase ≥2 and AKI occurring within 48 h of admission. The exposure was mean systolic BP over the first 48 h (seven measurements at baseline and every 8 h), categorized as ≤100, 101-120, 121-140, and >140 mmHg. Patients were followed for one year. The primary outcome was a composite of ≥25% decline in estimated glomerular filtration rate, long-term dialysis, and one-year mortality.
resultsOf 2,920 screened patients, 476 were included. Mean age was 68.4 ± 14.5 years, and 55% were male. AKI stages I, II, and III occurred in 55%, 21%, and 24%, respectively. The primary composite outcome was most frequent in the ≤100 mmHg group (80%) compared with 101-120 (51%), 121-140 (50%), and >140 mmHg (46%) (
conclusionIn non-critically ill patients with SA-AKI, early mean systolic BP ≤100 mmHg within 48 h was associated with worse one-year outcomes, driven largely by higher mortality. Early systolic BP may serve as a prognostic marker for high-risk patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.