Evidence map›Paper›PMID 42768866›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Unmasking preclinical Alzheimer's pathology: auditory distraction cost and occupational reserve jointly discriminate amyloid positivity in subjective cognitive decline.

Yating Wang, Yuanhong Chen, Haifan Kong, Weineng Chen, Fengjuan Su, Yifan Zheng, Yingying Fang, Lishan Lin, Jiayi Zhou, Yucheng Li and 9 more

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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

19 authors.

Yating Wang *Department of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yuanhong Chen *Department of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Haifan KongDepartment of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Weineng ChenDepartment of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Fengjuan SuDepartment of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yifan ZhengDepartment of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yingying FangDepartment of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Lishan LinDepartment of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Jiayi ZhouDepartment of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yucheng LiDepartment of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Ya ZhangDepartment of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Anqi HuangDepartment of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Michael F BergeronDepartment of Health Sciences, University of Hartford, West Hartford, Connecticut, USA.
James O Clifford JrDepartment of Psychology, College of San Mateo, San Mateo, California, USA.
J Wesson AshfordDepartment of Psychiatry & Behavioral Sciences, Stanford University, Palo Alto, California, USA.
Xianbo ZhouCenter for Alzheimer's Research, Washington Institute of Clinical Research, Vienna, Virginia, USA.
Zhongliang DaiDepartment of Anesthesiology, Shenzhen People's Hospital (The First Affliated Hospital, Southern University of Science and Technology), Shenzhen, China.
Wenli ShengDepartment of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Zhong PeiDepartment of Neurology, Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Funding

Guangdong Provincial Clinical Research Center for Neurological Diseases 2020B1111170002Guangdong Provincial Engineering Center for Major Neurological Disease TreatmentGuangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases 2020B1212060017Guangdong Provincial Translational Medicine Innovation Platform for Diagnosis and Treatment of Major Neurological DiseaseGuangzhou Clinical Research and Translational Center for Major Neurological Diseases 201604020010Shanghai Medical Innovation and Development Foundation Project K0601902Shenzhen Medical Research Fund c250130Southern China International Joint Research Center for Early Intervention and Functional Rehabilitation of Neurological Diseases 2015B050501003Southern China International Joint Research Center for Early Intervention and Functional Rehabilitation of Neurological Diseases 2020A0505020004the National Key Research and Development Program of China 2022YFA1104904the National Natural Science Foundation of China 82271266
6 · The paper itself

Abstract

introductionConventional cognitive instruments exhibit limited efficacy in detecting insidious cognitive decline in subjective cognitive decline (SCD) due to neural compensation. We hypothesized that auditory distraction during a visual memory task would unmask preclinical amyloid beta (Aβ) vulnerability.

methodsWe evaluated 112 participants (SCD and mild cognitive impairment [MCI]) using the MemTrax test under quiet and noisy conditions to quantify distraction costs (d-MTxc). Aβ status and cognitive reserve were assessed via positron emission tomography and the Cognitive Reserve Index questionnaire (CRIq).

resultsAβ-positive SCD individuals performed normally in quiet but showed higher d-MTxc than Aβ-negative peers (11.17 ± 5.762 vs 6.67 ± 5.096). Higher CRIq-WorkingActivity (CRIW) scores identified Aβ positivity and moderated performance. The combination of d-MTxc and CRIW accurately classified Aβ positivity (AUC = 0.836), whereas MCI individuals exhibited metabolic network fragmentation. DISCUSSION: Auditory distraction taxes cognitive capacity to expose compensatory failures coupled with Aβ burden. This paradigm, interacting with occupational reserve, offers a promising digital biomarker framework for preclinical Alzheimer's screening.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesCognitive DysfunctionCognitive ReserveAgedFemaleHumansMaleNeuropsychological TestsPositron-Emission TomographyAmyloid beta-PeptidesAlzheimer's diseasecognitive reservedistraction costMemTraxsubjective cognitive decline

Identifiers

PMID42768866
PMCPMC13594782

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.