ArticleRenal failure2026
Noncrystalline light-chain proximal tubulopathy: a retrospective study from a single institute of China.
Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Light-chain proximal tubulopathy (LCPT) is a rare disease, which is classified as crystalline or noncrystalline based on the cytoplasmic inclusions in the proximal tubules. This study aimed to investigate the clinical features of noncrystalline LCPT from a single institute of China. We retrospectively enrolled patients diagnosed with isolated noncrystalline LCPT by kidney biopsy at Peking University First Hospital between 2011 and 2024. We systematically analyzed clinical data, kidney pathological type, treatment and prognosis. Twenty patients were enrolled. The mean age at diagnosis was 58 ± 12 and the sex ratio was 4/16 (female/male). Mean proteinuria was 1.9 ± 2.3g/24 hr and the mean estimated glomerular filtration rate (eGFR) at the point of biopsy 57 ± 30 mL/min/1.73 m
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