ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Behavior determines times to care home admission and death in semantic dementia: Insights from a cohort of 90 cases.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionIn semantic dementia (SD), no consistent prognostic factors for early care home (CH) admission or mortality have been identified, despite their potential utility in care management.
methodsOver a 31-year period, we collected sociodemographic, neuroimaging, neuropsychological, and behavioral data within a large cohort of 90 SD patients. Survival and risk factor analyses were conducted to identify variables mostly influencing CH admission and/or death.
resultsHalf of the patients were admitted to CH 7.5 years after diagnosis, and half died after 8.4 years. Behavior emerged as the sole baseline prognostic factor and even mild behavioral disorders were linked to earlier CH admission (3.0 years) and shorter survival (3.6 years), without influence of the predominant side of anterior temporal atrophy. DISCUSSION: Behavioral disorders are a major risk factor for loss of independence in SD and a usable prognostic marker in clinical practice, regardless of the predominant side of temporal atrophy.
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