ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Do amyloid trajectories reach a ceiling? Evidence from iterative approximation and simulation.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Do amyloid trajectories reach a ceiling? Evidence from iterative approximation and simulation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
Corrections and comments
- Update of
Authors and funding
5 authors.
Funding
Abstract
introductionQualitative models of Alzheimer's disease (AD) pathology often posit that amyloid accumulation follows a sigmoid curve, indicating that the rate of deposition wanes over time. Longitudinal positron emission tomography (PET) data now allow us to investigate amyloid accumulation trajectories with greater detail and over longer follow-up periods.
methodsWe combine inferences from simulated amyloid trajectories, empirical PET data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), and the sampled iterative local approximation algorithm (SILA) to assess whether amyloid accumulation reaches a physiologic ceiling.
resultsSILA reliably detects a ceiling in simulated scenarios that impose a sigmoid shape. Fit to ADNI, SILA does not appear to indicate the presence of a ceiling. DISCUSSION: Amyloid trajectories may not reach a physiologic ceiling during the stages of AD typically observed while patients remain under follow-up in cohort studies. Illustrative models of biomarker cascades, while useful for conceptualizing pathologic processes, may not represent amyloid trajectory shapes accurately.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.