Evidence map›Paper›PMID 42768754›Full record

ArticleCancer medicine2026

Long-Term or Recurrent Antibiotic Use During Childhood or Adolescence and the Risk of Kidney Cancer: A Cohort Study.

Jiani Liu, Xiangyu Chen, Lina Jia, Xiaotong Jing, Xiaoyan Pan, Xingyu Zhang, Zhong Jing, Jinqiu Yuan, Qiangsheng He, Xiaoyu Dai

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In one paragraph

Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Jiani LiuMianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, China.
Xiangyu ChenDepartment of Nephrology, Meishan Second People's Hospital, Meishan, Sichuan, China.
Lina JiaCentral Sterile Supply Department, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Xiaotong JingSchool of Nursing, Wuhan University, Wuhan, China.ORCID https://orcid.org/0009-0001-5225-8930
Xiaoyan PanMianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, China.
Xingyu ZhangMianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, China.
Zhong JingDepartment of Nephrology, Mianyang 404 Hospital, Mianyang, China.
Jinqiu YuanClinical Research Institute, Center for Digestive Disease, the Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, Guangdong, China.
Qiangsheng HeClinical Research Institute, Center for Digestive Disease, the Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, Guangdong, China.
Xiaoyu DaiMianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, China.ORCID https://orcid.org/0000-0001-5328-1473

Funding

Mianyang Healthcare Commission Project Fund 202005Sichuan Province Youth Innovation Research Project Fund Q22098the 2024 Open Research Fund of the NHC Key Laboratory of Nuclear Technology Medical Transformation 2024HYX031
6 · The paper itself

Abstract

backgroundAntibiotic use has been associated with cancer risk, but evidence regarding early-life antibiotic use and kidney cancer is limited. This study aimed to examine the association between long-term or recurrent antibiotic use (LRAU) during childhood or adolescence and kidney cancer risk and to assess the potential mediating role of adult adiposity.

methodsThis cohort study included 147,605 participants from the UK Biobank. We included participants with information on LRAU during childhood or adolescence who were free of cancer prior to baseline. Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between LRAU during childhood or adolescence and kidney cancer risk. Mediation analyses were performed to evaluate the potential mediating role of adiposity.

resultsLRAU during childhood or adolescence was associated with a 48% higher risk of incident kidney cancer after adjustment for potential confounders (HR 1.48, 95% CI 1.08-2.02). The proportion of the observed association between LRAU and kidney cancer mediated by adiposity measures ranged from 4.3% for waist-to-hip ratio to 13.2% for body fat percentage.

conclusionsLRAU during childhood or adolescence was associated with a higher risk of kidney cancer, and mediation analyses suggested that adult adiposity may partially mediate this association. Further studies using prospectively recorded prescription and indication data are needed to replicate these findings.

Indexed as

Anti-Bacterial AgentsKidney NeoplasmsAdiposityAdolescentAdultChildCohort StudiesFemaleHumansIncidenceMaleMiddle AgedProportional Hazards ModelsRisk FactorsUnited KingdomAnti-Bacterial Agentsadiposityantibiotic usecohortkidney cancerUK biobank

Identifiers

PMID42768754
PMCPMC13594567

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