Evidence map›Paper›PMID 42768268›Full record

ArticleNeurocritical care2026

Pediatric Neurogenic Stunned Myocardium: A Systematic Review and Pooled Individual-Level Analysis.

Cédérick Montplaisir, Sudarsan Packirisamy, Nick Lee, Farbod Niazi, Aline Han, Catherine Korman, Nicolas Phaneuf-Garand, Tristan Brunette-Clément, Kenza S Lahlou, Xavier Carmona and 6 more

Abstract read
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In one paragraph

Article in Neurocritical care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Cédérick MontplaisirFaculty of Medicine, University of Montreal, Montreal, QC, Canada.
Sudarsan PackirisamyFaculty of Medicine, University of Montreal, Montreal, QC, Canada.
Nick LeeFaculty of Medicine, University of Montreal, Montreal, QC, Canada.
Farbod NiaziFaculty of Medicine, University of Montreal, Montreal, QC, Canada.
Aline HanFaculty of Medicine, University of Montreal, Montreal, QC, Canada.
Catherine KormanBrain and Development Research Axis, Sainte-Justine Research Center, Montreal, QC, Canada.
Nicolas Phaneuf-GarandFaculty of Medicine, University of Montreal, Montreal, QC, Canada.
Tristan Brunette-ClémentBrain and Development Research Axis, Sainte-Justine Research Center, Montreal, QC, Canada.
Kenza S LahlouFaculty of Medicine, University of Montreal, Montreal, QC, Canada.
Xavier CarmonaFaculty of Medicine, University of Montreal, Montreal, QC, Canada.
Alexie Pellan-SayeghFaculty of Medicine, University of Montreal, Montreal, QC, Canada.
Dominic VenneDivision of Neurosurgery, Department of Surgery, Sainte-Justine University Hospital Centre, Montreal, QC, Canada.
Genevieve Dupont-ThibodeauCritical Care Service, Department of Pediatrics, Sainte-Justine University Hospital Centre, Montreal, QC, Canada.
Michel W BojanowskiDivision of Neurosurgery, Department of Surgery, University of Montreal Hospital Center (CHUM), Montreal, QC, Canada.
Aristides HadjinicolaouBrain and Development Research Axis, Sainte-Justine Research Center, Montreal, QC, Canada.
Alexander G WeilBrain and Development Research Axis, Sainte-Justine Research Center, Montreal, QC, Canada. alexander.weil.med@ssss.gouv.qc.ca.ORCID http://orcid.org/0000-0003-4162-6096

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeurogenic stunned myocardium (NSM) is a reversible cardiac dysfunction after acute neurological injury that is well described in adults but poorly characterized in children.

objectiveThe purpose of this study was to characterize pediatric NSM and identify factors associated with neurological outcome using individual patient data (IPD).

methodsA systematic review and pooled individual-level analysis were conducted according to Meta-analysis Of Observational Studies in Epidemiology (MOOSE) guidelines. PubMed, Web of Science, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) were searched from inception to November 2025 for studies reporting patients ≤ 18 years with NSM and available outcome data. Demographic, neurological, and cardiac variables were extracted. Functional outcomes were assessed using the modified Rankin Scale (mRS).

resultsA total of 29 studies comprising 38 patients were included (mean age 7.7 years). The mean time to NSM onset was 60.8 h after neurological injury. Ventricular dysfunction occurred in 94.7%, commonly basal hypokinesis. Favorable outcome (mRS 0-2) occurred in 71.1%, while cardiac arrest occurred in 26.3% and mortality in 23.7%. Subarachnoid hemorrhage was associated with a worse outcome, whereas absence of pupil abnormalities and preserved reflexes were associated with a favorable outcome.

conclusionsPediatric NSM is usually reversible with favorable neurological outcomes but remains associated with significant morbidity and mortality. Early recognition and multidisciplinary management may improve outcomes. Larger prospective studies are needed to refine prognostic stratification.

Indexed as

Brain injuriesHeart diseasesMyocardial stunningPediatricsSystematic review

Identifiers

PMID42768268

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.