ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2026
Antibacterial efficacy of Nonea lutea-mediated silver and gold nanoparticles against multidrug-resistant clinical pathogens harboring virulence and resistance genes.
Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionThe emergence of high-level antibiotic-resistant bacteria, such as Pseudomonas aeruginosa, Acinetobacter baumannii, and Staphylococcus aureus, represents a critical global health threat that requires novel therapeutic strategies. The use of Green-synthesized gold and silver nanoparticles is a suitable solution, and Nonea lutea plant, due to its promising phytochemical properties and traditional medicinal uses, can be used for this purpose. This study aimed to investigate the antimicrobial effect of these nanoparticles on multidrug-resistant (MDR) isolates carrying multiple virulence and resistance genes. MATERIALS AND
methodsOne-hundred clinical isolates of each organism were collected and identified. Antibiotic resistance pattern of them was investigated by disk agar diffusion method. Bacterial DNA was extracted by alkaline lysis method and the presence of virulence and antibiotic resistance genes was assessed using PCR. Then, 15 MDR isolates of each organism containing multiple virulence genes were selected. Green-synthesized silver and gold nanoparticles from methanolic extract of N. lutea were prepared and their minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were evaluated against the isolates.
resultsAll 15 MDR P. aeruginosa isolates harbored the exoU, exoA, bla
conclusionGreen-synthesized silver nanoparticles demonstrated promising in vitro antibacterial activity against MDR isolates. However, further mechanistic and in vivo studies are required to fully assess their therapeutic potential.
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