ArticleMolecular imaging and biology2026
In Vivo Quantification of Myelin Injury Following Ischemic Stroke.
Article in Molecular imaging and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeIschemic stroke involves substantial myelinated white matter injury, a key cause of long-term neurological deficits. However, conventional MRI often lacks sufficient sensitivity and specificity to detect myelin pathology and resolve lesional heterogeneity, limiting accurate correlation with clinical outcomes and prognostic assessment. To address this limitation, we recently developed a myelin-targeted PET radiotracer, [ PROCEDURES: Dynamic [
resultsIn MCAO rats, tracer uptake was significantly reduced in the lesioned hemisphere (SUV ratio: 0.64 ± 0.08, P < 0.001), closely correlating with histological myelin loss. In the non-human primate, infarcted regions exhibited up to 60% SUV reduction in SUV, while stroke patients demonstrated 26-43% lower uptake in infarct cores. Notably, these reductions persisted after perfusion correction. Furthermore, voxel-level analyses revealed pathological heterogeneity within lesions that appeared homogeneous on MRI.
conclusionsThis translational study in rodent model, non-human primates, and human patients demonstrates that [
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