Evidence map›Paper›PMID 42768225›Full record

ArticleTropical animal health and production2026

Hepatic and renal histopathological changes in lambs fed sisal mucilage silage with or without moisture-absorbing additives.

Vitor Marques de França, Manoel Francisco de Sousa, Tomás Guilherme Pereira da Silva, João Vitor Fernandes Clemente, Emanuel Felipe de Oliveira Filho, Valdemiro Amaro da Silva Júnior, Paulo Sérgio de Azevedo, Edson Mauro Santos, Francisco Fernando Ramos de Carvalho, Adriana Guim and 1 more

Abstract read
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In one paragraph

Article in Tropical animal health and production, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vitor Marques de FrançaDepartment of Veterinary Medicine, Federal Rural University of Pernambuco, Dom Manuel de Medeiros Street, s/n, Dois Irmãos, Recife, PE, 52171-900, Brazil.
Manoel Francisco de SousaBrazilian Agricultural Research Corporation (EMBRAPA) - Cotton, Oswaldo Cruz Street, 1143, Centenário, Campina Grande, PB, 58428-095, Brazil.ORCID http://orcid.org/0009-0008-3281-3731
Tomás Guilherme Pereira da SilvaFederal Institute of Education, Science and Technology of Sergipe (IFS), Propriá Campus, Rodovia BR 101, Km 5, s/n, Centro, Propriá, SE, 64750-000, Brazil. tomas-g@hotmail.com.ORCID http://orcid.org/0000-0002-6115-5474
João Vitor Fernandes ClementeDepartment of Animal Science, Federal Rural University of Pernambuco, Dom Manuel de Medeiros Street, s/n, Dois Irmãos, Recife, PE, 52171-900, Brazil.ORCID http://orcid.org/0000-0001-8562-5015
Emanuel Felipe de Oliveira FilhoBarra Multidisciplinary Center, Federal University of Western Bahia, Av. 23 de Agosto, s/n, Assunção, Barra, BA, 47100-000, Brazil.ORCID http://orcid.org/0000-0003-2836-5549
Valdemiro Amaro da Silva JúniorDepartment of Veterinary Medicine, Federal Rural University of Pernambuco, Dom Manuel de Medeiros Street, s/n, Dois Irmãos, Recife, PE, 52171-900, Brazil.ORCID http://orcid.org/0000-0002-1894-7337
Paulo Sérgio de AzevedoDepartment of Animal Science, Federal University of Paraíba, Rodovia PB 79, Km 12, s/n, Bairro Universitário, Areia, PB, 58397-000, Brazil.ORCID http://orcid.org/0000-0002-7603-5141
Edson Mauro SantosDepartment of Animal Science, Federal University of Paraíba, Rodovia PB 79, Km 12, s/n, Bairro Universitário, Areia, PB, 58397-000, Brazil.ORCID http://orcid.org/0000-0003-2832-6603
Francisco Fernando Ramos de CarvalhoDepartment of Animal Science, Federal Rural University of Pernambuco, Dom Manuel de Medeiros Street, s/n, Dois Irmãos, Recife, PE, 52171-900, Brazil.ORCID http://orcid.org/0000-0001-9211-0263
Adriana GuimDepartment of Animal Science, Federal Rural University of Pernambuco, Dom Manuel de Medeiros Street, s/n, Dois Irmãos, Recife, PE, 52171-900, Brazil.ORCID http://orcid.org/0000-0002-6589-9104
Pierre Castro SoaresDepartment of Veterinary Medicine, Federal Rural University of Pernambuco, Dom Manuel de Medeiros Street, s/n, Dois Irmãos, Recife, PE, 52171-900, Brazil.ORCID http://orcid.org/0000-0002-5680-3940

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the effects of diets containing sisal mucilage silage, with or without moisture-absorbing additives, on the hepatic and renal histopathological profiles of lambs. Eighteen Soinga lambs (average initial body weight of 19 ± 1.38 kg) were allocated in a completely randomized design among three diets: sisal mucilage silage without additive (SMS); sisal mucilage silage ensiled with wheat bran (SMS-WB); and sisal mucilage silage ensiled with ground corn (SMS-GC). The experimental period lasted 60 days, after 14 days of adaptation to the diets. SMS without additives induced severe hepatic coagulative necrosis and microvesicular steatosis, alongside moderate-to-severe renal proliferative glomerulonephritis and glomerular atrophy. SMS-WB acted as a potent hepatoprotector, completely preventing macrovesicular steatosis and pericentral necrosis while down-grading microvesicular steatosis to a mild degree. In the kidneys, SMS-GC provided the most effective glomerular protection, mitigating both proliferative glomerulonephritis and glomerular atrophy to mild intensities. On the other hand, SMS-WB reduced only glomerular atrophy to a mild level, failing to contain proliferative glomerulonephritis. Renal medullary dystrophic calcification remained unaltered across all treatments (66.6%), indicating an intrinsic lesion profile of sisal mucilage ingestion. In conclusion, while sisal mucilage silage exhibits intrinsic hepatorenal toxicity in lambs, the use of moisture-absorbing additives is a viable mitigation strategy. Wheat bran serves as an effective hepatoprotector, whereas ground corn provides superior glomerular preservation. Therefore, the strategic inclusion of these additives is crucial to enable the safe use of sisal by-products in ruminant nutrition without compromising animal health.

Indexed as

KidneyLiverPlant MucilageSheep, DomesticSilageAnimal FeedAnimalsDietDietary FiberMaleRandom AllocationSheepDietary FiberPlant MucilageAgave sisalanaEnsilageOxalatesSaponinsSmall ruminantsTissue lesions

Identifiers

PMID42768225
PMCPMC13593729

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.