Evidence map›Paper›PMID 42768187›Full record

ArticleSpine deformity2026

Low bone mineral density in non-ambulatory adolescents relates to lower correction of neuromuscular scoliosis after posterior spinal fusion.

Konstantinos Tsaknakis, Clara Knieriem, Charlotte Scheulen, Venla Soini, Katja A Lüders, Lena Braunschweig, Luise Metzger, Jan-Henrik Kreuzer, Katharina Jäckle, Heiko M Lorenz and 1 more

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Article in Spine deformity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Konstantinos TsaknakisPediatric Orthopaedics, Department of Trauma, Orthopaedic and Plastic Surgery, University Medical Center Goettingen, 37075, Goettingen, Germany.
Clara KnieriemPediatric Orthopaedics, Department of Trauma, Orthopaedic and Plastic Surgery, University Medical Center Goettingen, 37075, Goettingen, Germany.
Charlotte ScheulenPediatric Orthopaedics, Department of Trauma, Orthopaedic and Plastic Surgery, University Medical Center Goettingen, 37075, Goettingen, Germany.
Venla SoiniDepartment of Paediatric Surgery and Paediatric Orthopaedic Surgery, University of Turku and Turku University Hospital, Turku, Finland.
Katja A LüdersPediatric Orthopaedics, Department of Trauma, Orthopaedic and Plastic Surgery, University Medical Center Goettingen, 37075, Goettingen, Germany.
Lena BraunschweigPediatric Orthopaedics, Department of Trauma, Orthopaedic and Plastic Surgery, University Medical Center Goettingen, 37075, Goettingen, Germany.
Luise MetzgerPediatric Orthopaedics, Department of Trauma, Orthopaedic and Plastic Surgery, University Medical Center Goettingen, 37075, Goettingen, Germany.
Jan-Henrik KreuzerPediatric Orthopaedics, Department of Trauma, Orthopaedic and Plastic Surgery, University Medical Center Goettingen, 37075, Goettingen, Germany.
Katharina JäcklePediatric Orthopaedics, Department of Trauma, Orthopaedic and Plastic Surgery, University Medical Center Goettingen, 37075, Goettingen, Germany.
Heiko M LorenzPediatric Orthopaedics, Department of Trauma, Orthopaedic and Plastic Surgery, University Medical Center Goettingen, 37075, Goettingen, Germany.
Anna K HellPediatric Orthopaedics, Department of Trauma, Orthopaedic and Plastic Surgery, University Medical Center Goettingen, 37075, Goettingen, Germany. anna.hell@med.uni-goettingen.de.ORCID http://orcid.org/0000-0002-6655-7130

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNon-ambulatory adolescents with neuromuscular scoliosis (NMS) often require surgical intervention. The purpose of this study was to examine whether low bone mineral density (BMD) affects the results of posterior spinal fusion.

methodsVolumetric BMD (vBMD) was measured in preoperative computed tomography (CT) scans of scoliotic patients with Duchenne Muscular Dystrophy (DMD), Spinal Muscular Atrophy (SMA), Cerebral Palsy (CP) and Rett syndrome (RTT). CT scans of healthy age-matched adolescents were used to define reference vBMD values and to calculate Z-scores. Scoliosis angles were measured in preoperative and postoperative radiograms to evaluate neuromuscular spinal deformity correction.

resultsInitial scoliosis angles of 169 patients with NMS were 83 ± 31°. PSF improved deformities to 33 ± 21° with an overall correction of 60.8 ± 16.4%. All patients (n=169) had significantly lower vBMD values in comparison to age-matched healthy controls (n=87). Patients with DMD (n=55) had lowest vBMD for age values, followed by patients with SMA (n=34), CP (n=52) and RTT (n=28). Significantly lower Z-scores (- 2.5±1.5 versus - 1.7±1.3) were found in adolescents with poor scoliosis correction in comparison to those with good results. A higher initial scoliosis angle had a negative effect on the deformity correction (R

conclusionAll adolescents with NMS had significantly lower vBMD in comparison to age-matched controls. Lower vBMD values were associated with poor spinal deformity correction of 60% and less.

Indexed as

Bone mineral densityCerebral palsyDuchenne muscular dystrophyPosterior spinal fusionRett syndromeScoliosisSpinal muscular atrophy

Identifiers

PMID42768187

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.