ArticleCommunications medicine2026
Naive T cell-depleted hematopoietic stem cell transplantation to minimize immunosuppression after solid organ transplantation: case report.
Article in Communications medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06997471 (A Phase I, Single-Center, Open-Label Trial to Assess the Safety and Tolerability of Delayed Infusion of a Naïve T Cell Depleted Hematopoietic Graft and Memory T-lymphocytes in Recipients of Solid Organ Transplantation), which is not on this map. Not yet cited in PubMed.
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A Phase I, Single-Center, Open-Label Trial to Assess the Safety and Tolerability of Delayed Infusion of a Naïve T Cell Depleted Hematopoietic Graft and Memory T-lymphocytes in Recipients of Solid Organ Transplantation
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28 authors.
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Abstract
backgroundSolid organ transplantation (SOT) outcomes remain suboptimal due to graft rejection, drug-related complications and comorbidities. Hematopoietic stem cell transplantation (HSCT) has been explored to induce chimerism and tolerance, reducing reliance on immunosuppression.
methodsWe report two patients who, post-SOT, received non-myeloablative conditioning followed by a naïve T-cell-depleted HSCT and memory T-cell (CD45RA⁻) donor lymphocyte infusions under a compassionate use program. Mixed lymphocyte reaction (MLR) experiments performed 41 (Patient #1) and 31 (Patient #2) months after SOT/HSCT and TCRβ deep Illumina sequencing, together with clonotype frequency analysis, were used to identify donor-reactive T-cell clonotypes.
resultsBoth patients were maintained in minimal immunosuppression with no signs of rejection more than 5 years after the SOT/HSCT. Recipient cells resulted hyporesponsive to donor and third-party cells, yet retained reactivity to CMV infection. TCRβ profiling provided an overview of the lymphocyte subpopulations before and after transplantation. Donor-reactive clonotypes potentially associated with rejection were identified pre-HSCT and monitored after this procedure.
conclusionsOur clinical strategy is a feasible, safe approach to induce transient mixed chimerism and may support minimization of immunosuppression following SOT. Despite considerable heterogeneity between patients - affected organ, donor source (deceased/living), and HLA compatibility (fully mismatched/matched sibling) -, we consider our findings to provide a valuable foundation for development of a clinical trial recently started at our hospital: A phase I, single-center, open-label trial to assess safety and tolerability of delayed infusion of a naïve T-cell-depleted hematopoietic graft and memory T-lymphocytes in recipients of solid organ transplantation (NCT06997471).
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