Evidence map›Paper›PMID 42768105›Full record

ArticleNature metabolism2026

Gut microbiome maturation in early childhood interacts with host genetics to predict type 1 diabetes risk.

Danyue Dong, Aaron M Walsh, Tommi Vatanen, George Weingart, Mondher Khdhiri, Meir J Stampfer, Kendra Vehik, Eric A Franzosa, Curtis Huttenhower, Dong D Wang and 1 more

Abstract read
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In one paragraph

Article in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Danyue DongChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0009-0003-3256-2876
Aaron M WalshBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Tommi VatanenBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-0949-1291
George WeingartDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Mondher KhdhiriBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Meir J StampferChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Kendra VehikHealth Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.ORCID http://orcid.org/0000-0001-6243-6772
Eric A FranzosaBroad Institute of MIT and Harvard, Cambridge, MA, USA. franzosa@hsph.harvard.edu.ORCID http://orcid.org/0000-0002-8798-7068
Curtis HuttenhowerBroad Institute of MIT and Harvard, Cambridge, MA, USA. chuttenh@hsph.harvard.edu.ORCID http://orcid.org/0000-0002-1110-0096
Dong D WangChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. dow471@mail.harvard.edu.ORCID http://orcid.org/0000-0002-0897-3048
TEDDY Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prospective evidence linking early-life microbiome development and host genetics with type 1 diabetes (T1D) risk is limited. Here, we describe how gut microbiome maturation and host genetics influence T1D risk in the TEDDY study. We analysed 12,151 longitudinal metagenomes and host genetic data from 887 children at high genetic risk for T1D followed for up to 6 years. We identify three microbiome maturational patterns: Early Matured, Late Matured and Early Plateaued, driven primarily by non-linear changes in species from the Bifidobacterium and Ruminococcus genera. The Early Matured pattern is enriched in galactose metabolism and exhibits higher production of aromatic amino acids and B-group vitamins at early follow-ups, whereas the Early Plateaued pattern has increased microbial production of branched-chain amino acids. Notably, the Early Plateaued pattern is associated with a threefold elevated risk of T1D, whereas other patterns are not associated with T1D risk. Furthermore, we find that host genetic variants related to antimicrobial and antiviral immune responses modify the association between the Late Matured pattern and T1D risk. These findings highlight the role of early microbial exposures and host genetics in T1D susceptibility.

Identifiers

PMID42768105

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.