ArticleEuropean journal of clinical nutrition2026
Vitamin B12 absorption and factors associated with the response to long-term oral B12 supplementation: a secondary analysis of data from a B12-deficient Indian rural community.
Article in European journal of clinical nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe absorption of oral vitamin B12 (B-12) and predictors of its long-term supplementation are not well understood in populations with B-12 insufficiency.
objectiveIn a secondary data analysis of a B-12 absorption study and a supplementation trial in a B-12 insufficient rural Indian community, we examined (i) the distribution of plasma holotranscobalamin (holoTC) responses during an absorption test, and (ii) predictors of B-12 status during long-term, oral supplementation with physiological and near-physiological doses of B-12.
methodsParticipants in the Pune Maternal Nutrition Study first underwent a B-12 absorption study (CobaSorb protocol) and subsequently participated in a 12-month double-blind randomized controlled trial of daily oral B-12 (0, 2, or 10 µg cyanocobalamin) and folic acid (0 or 200 µg). Plasma holoTC responses during absorption test were characterized, and linear mixed-effects models used to identify predictors of B-12 absorption and response during long-term supplementation.
resultsParticipants (313) included children (n = 109, mean age 9 y, weight 21.9 kg, BMI 13.6 kg/m
conclusionsThe holoTC response during B-12 absorption test predicted subsequent biomarker responses to long-term B-12 supplementation, linking absorptive capacity with metabolic correction. These findings provide a mechanistic framework for understanding variability in response to oral B-12 replenishment.
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