Ru-enabled dehydration-reductive amination of α-, β-hydroxy acids into amino acids.

Shixiang Feng, Jun Yi, Huirong Yu, Jie He, Di Xu, Xinbin Ma, Ning Yan, Li Shuai

Abstract read

In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shixiang Feng *College of Materials Engineering, Fujian Agriculture and Forestry University, Fuzhou, China.

Jun Yi *Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, China.ORCID http://orcid.org/0000-0003-1152-7783

Huirong YuCollege of Materials Engineering, Fujian Agriculture and Forestry University, Fuzhou, China.

Jie HeCollege of Chemical Engineering, Fuzhou University, Fuzhou, China.

Di XuJoint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Fuzhou, China.ORCID http://orcid.org/0000-0003-3536-4173

Xinbin MaJoint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Fuzhou, China.ORCID http://orcid.org/0000-0002-2210-0518

Ning YanJoint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Fuzhou, China. ning.yan@nus.edu.sg.ORCID http://orcid.org/0000-0002-1877-9206

Li ShuaiCollege of Materials Engineering, Fujian Agriculture and Forestry University, Fuzhou, China. lishuai@fafu.edu.cn.ORCID http://orcid.org/0000-0002-7404-815X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The direct transformation of biomass derived α-, β-hydroxy acids into amino acids is attractive but not reported. Here we disclose an atomically dispersed Ru catalyst that unlocks a previously unrecognized dehydration-reductive amination mechanism for the selective synthesis of amino acids from α-, β-hydroxy acids. Structural characterizations confirm the presence of isolated, partially oxidized Ru centers, which selectively mediates base-assisted α-H abstraction and β-OH elimination, while simultaneously enabling direct reductive amination of the resulting enol/enolate intermediates, bypassing the conventional α-keto acid pathway. The identified dehydration-reductive amination pathway and associate Ru-based catalyst opens opportunities for transforming a wide range of biomass-derived polyols containing adjacent hydroxyl groups into useful amino-functionalized products.

Indexed as

Amino AcidsHydroxy AcidsRutheniumAminationCatalysisOxidation-ReductionAmino AcidsHydroxy AcidsRuthenium

Identifiers

PMID42768059

DOI10.1038/s41467-026-77053-7

PMCPMC13594111

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.