ArticleeNeuro2026
Cardiopulmonary Effects of Vagus Nerve Stimulation in Mice.
Article in eNeuro, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Vagus nerve stimulation (VNS) is an FDA-approved treatment for epilepsy, depression, and chronic stroke. While the effects of VNS are widely studied in rats and large animal models, few studies have characterized VNS in mice due to the practical challenges associated with their small size. However, mouse genetic tools provide a powerful opportunity to elucidate the diverse mechanisms underlying the many effects of VNS. Therefore, to inform the expanding use of mouse models in VNS research, we characterized the cardiopulmonary effects of left versus right VNS in anesthetized C57BL/6 mice. VNS robustly drove decreases in heart rate (HR) and breathing rate (BR) in the majority of mice. VNS-driven changes in BR were not correlated with changes in HR. We found no differences between male and female mice nor in the effects of left versus right VNS. VNS-induced bradycardia was abolished by transection of efferent vagal fibers, consistent with direct descending vagal control of cardiac rhythmicity. In contrast, VNS-driven changes in BR were abolished by both afferent and efferent vagotomies, consistent with the involvement of central feedback circuits in bilaterally coordinated vagal modulation of respiration. These results further our understanding of VNS effects in mice and help inform experimental design and cuff validation protocols for vagal modulation of peripheral versus central circuits in this species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.