Observational studyBMJ open2026
SKIN-BAR project: protocol for a prospective cohort study investigating skin barrier function and pressure injury development in critically ill adults.
Observational study in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07560683 (Investigation of Skin Barrier Function Using Biosensor Methods in Risky Skin Regions and Developed Pressure Injuries in Intensive Care Patients, and Identification of Influencing Factors), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigation of Skin Barrier Function Using Biosensor Methods in Risky Skin Regions and Developed Pressure Injuries in Intensive Care Patients, and Identification of Influencing Factors: The SKIN-BAR Project
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPressure injuries (PIs) remain a common and costly complication among critically ill patients despite advances in prevention strategies. Current assessment methods rely primarily on visual skin inspection and risk assessment tools, which may fail to detect early physiological alterations preceding visible tissue damage. Biophysical parameters, including transepidermal water loss, stratum corneum hydration, skin pH and skin temperature, have emerged as promising indicators of skin barrier dysfunction; however, longitudinal evidence in intensive care populations remains limited. This study aims to investigate temporal changes in skin barrier function in pressure injury-prone and affected skin and to identify clinical and physiological factors associated with skin barrier dysfunction and pressure injury development. METHODS AND ANALYSIS: The SKIN-BAR project is a prospective observational cohort study to be conducted in an adult intensive care unit in Turkey. A total of 165 critically ill adults will be recruited and followed throughout their intensive care unit (ICU) stay. Skin barrier function will be assessed using non-invasive measurements of transepidermal water loss, stratum corneum hydration, skin pH and skin temperature. Measurements will be obtained within the first 4 hours of ICU admission, at 24, 48, 72 and 96 hours, on day 14, and weekly thereafter until ICU discharge. Clinical, laboratory, treatment-related and nursing care variables will also be collected. Linear mixed-effects models will be used to examine longitudinal changes in skin barrier function, while discrete-time survival analysis will be used to evaluate factors associated with incident pressure injury development. ETHICS AND DISSEMINATION: Ethical approval has been obtained from the Institutional Research Ethics Committee. Written informed consent will be obtained from participants or their legally authorised representatives before enrolment. Findings will be disseminated through publication in peer-reviewed journals, presentations at national and international scientific conferences and other academic dissemination activities. TRIAL REGISTRATION NUMBER: NCT07560683.
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